Wanting a fresh start after a broken relationship and a stressful job in the UK, Dr. Ruby Walker takes a job in India. Although she applied to work at a new urban clinic, Ruby ends up at the overcrowded and underfunded Good Karma Hospital run by the formidable Dr. Lydia Fonseca. As she adjusts to her new life in rural India, Ruby slowly realizes that the hospital may be more than the rundown medical outpost it appears to be.
The charismatic Sir Lionel Frost considers himself to be the world's foremost investigator of myths and monsters. Mr. Link only wants to find the missing branch of his sasquatch family, the yeti of Tibet, and hires Sir Frost to help him search. Unfortunately, Adelina Fortnight -- a fierce woman who has crossed paths with Sir Frost before -- holds the only map, and they are pursued by a villain hired by the Adventuring Society who would like Mr. Link's...
A tragic case leads Samir and Mari to grow closer still. Tensions run high when Lydia treats best friends with different faiths. Niki gives Bobby the opportunity for independence he so desperately craves but feels the full force of tiger mom Frankie when she discovers what Niki has done. A familiar face returns to Good Karma, but will he find the forgiveness he's looking for?
Ruby is shocked when Gabriel reappears in her life and insists on helping care for her father. Can she really be expected to trust him again? A misstep teaches Niki the dangers of overconfidence, but Ram reminds her what's important for a doctor. Samir and Mari return Karishma to her village and enjoy the celebrations that greet them. Lydia is forced to confront her past and question her future.
Lydia is forced to admit a highly contagious Nipah patient into her hospital when Ruby and new British Asian doctor Samir break protocol in the fight to save the girl's life. Ram is livid when he discovers that new headstrong trainee doctor, Dr. Niki Sharma, has ignored him and broken patient confidentiality. Greg helps two holidaymakers, but his good deed lands him in trouble with the law.
The happy news that Karishma is awake is offset by her loneliness. Realizing she needs more than medicine to fix her, Samir arranges a little magic. Niki volunteers to help Frankie find her missing son, and when they do, Niki discovers that empathy may be the best medicine, although Frankie's cancer worries require urgent tests. Meanwhile, Lydia learns there's only one answer to Greg's visa issue.
Ruby faces difficult questions when her actions have devastating consequences. Bobby ends up as a reluctant patient at Good Karma and decides to take matters into his own hands, much to Frankie's dismay. Lydia hides how impressed she is with Samir but rewards his efforts with a job offer. Greg discovers that getting arrested has alerted immigration to the fact that he doesn't have a visa.
Lydia and Greg's wedding plans are upset by three emergency admissions. Greg wonders if disappearing to help her patients is a ploy and in truth, Lydia has cold feet. Will they tie the knot? Matchmaker Niki decides to intervene with Mari and Samir and is delighted with the positive results. With the power dynamics between Ruby and Gabriel finally addressed, Ruby must decide what she wants.
British ex-pat Dr. Ruby Walker has left the Good Karma Hospital to practice as a GP near her family in rural India. But when a medical crisis forces her to return, Ruby must make peace with the hospital's intimidating head, Dr. Lydia Fonseca, and face her handsome but reticent colleague, Dr. Gabriel Varma. Just as Ruby feels ready to rekindle her romance with Gabriel, the sudden arrival of his former mentor, brilliant and beautiful plastic surgeon...
Ruby lashes out after learning the truth about her father and refuses to talk to Gabriel about it. Back at the hospital, Lydia helps a pregnant woman carrying twins, and Paul brings in a young woman who believes herself to be a goddess.
A heat wave causes problems at the hospital, tying up the staff with multiple cases of heatstroke and dehydration. Ruby makes a home visit to a patient with suspected appendicitis and later performs her first surgical operation, supervised by Gabriel.
When a building collapses near a busy marketplace, the hospital staff rush to treat the victims, and Ruby bonds with a patient who needs an emergency amputation. Greg invites Paul out for drinks with his friends, but Paul worries the outing will look like a double date.
After sparring with an herbal remedies provider in the local market, Lydia follows up with a former patient refusing care. Ruby contends with a dishonest patient, and newly widowed Paul returns to India.
After receiving a letter from her uncle, Ruby arranges a mobile clinic that's a five-hour drive away, and Lydia forces Gabriel to accompany her. Lydia attends to a victim of domestic abuse, while Greg tries to help Paul out of his rut by taking him to the Makar Sankranti kite festival.