Dave Seville, a struggling songwriter, comes across a trio of singing chipmunks, Alvin, Simon, and Theodore, who at first bring success until they are exploited by a record producer who Dave must rescue them from.
The vacationing Chipmunks and Chipettes are turning a luxury cruise liner into their personal playground, until they become 'chipwrecked' on a remote island. As the 'Munks' and Chipettes try various schemes to find their way home, they accidentally discover their new turf is not as deserted as it seems.
When a concert mishap lands Dave in the hospital, the Chipmunks take a break from superstardom and enroll in school to fit in with kids their age. But they soon face some stiff competition when they meet the Chipettes, a beautiful, talented trio of chipmunks.