Gru delights in all things wicked. Surrounded by an army of tireless little yellow minions, and armed with his arsenal of shrink rays, freeze rays, and battle-ready vehicles for land and air, he vanquishes all who stand in his way. Until the day he encounters the immense will of three little orphaned girls who look at him and see something that no one else has ever seen: a potential dad.
When his band votes him out due to his embarrasing musical antics, Dewey has to make the rent somehow. After intercepting a call for his substitute-teacher roomie Ned, Dewey finds himself in front of a class of elite elementary school students. Dewey decides to take on the music program and makes it his goal to teach them the gospel of rock and roll. His ulterior motive is to get them to compete against his former band for a cash prize.
Halfway through a ten-year mission, a group of astronauts becomes unstable, overcome by the isolation of deep space. While they prepare to return home, Earth is hit by a catastrophic event. The haunting emptiness of space becomes the least of their concerns as they fight to survive against unforeseen threats.