Peopling its landscape are Dorothea Brooke, a young idealist whose search for intellectual fulfillment leads her into a disastrous marriage to the pedantic scholar Casaubon; the charming but tactless Dr. Lydgate, whose marriage to the spendthrift beauty Rosamund and pioneering medical methods threaten to undermine his career; and, the religious hypocrite Bulstrode, hiding scandalous crimes from his past.
In nineteenth-century England, Dorothea Brooke's wishes to defy social conventions are inhibited by the strict nature of her surroundings.